Sustained Release Formulation: A Boon for Anti-diabetic Medications

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Sustained release formulation

In India, on average, more than 80% of people are suffering from diseases (either chronic or temporary), and for their treatment and management, they depend on medicine. The medicines are available in both conventional dosage forms (immediate release dosage forms) and modified drug release dosage forms (i.e., sustained release).

So let us enlighten you! What is a sustained-release formulation and why is it preferred over a conventional one?

During the formulation of any medicine, patient compliance and safety are the primary concerns.

What is the sustained-release formulation?

Sustained release formulation is defined as the dosage form, designed to release the drug (active substance) at a predetermined rate to achieve the desired drug concentration in the blood plasma or target site for a specific period of time.

Sustained release formulation facilitates both temporal (time-related) and spatial (target site-related) therapeutic benefits.

The main objective of sustained-release formulations is to provide an extended duration of action for medicaments with minimal side effects and thus improve patient compliance.

Advantages of sustained release formulation:

  • Reduction in dosing frequency ( frequency of drug administration)
  • Improve patient compliance
  • Maintain a uniform level of drug in plasma
  • Reduction in the amount of dose.
  • Reduce the local as well as systemic toxicity by direct delivery of the drug to the target site.
  • Increased stability of the drug.

Sustained release formulations play a vital role in the management of chronic diseases such as diabetes mellitus (DM). In the current scenario, India has the largest number of patient with diabetes in the world. So, almost everyone is familiar with DM.

A brief about what is diabetes? What is the third line antidiabetic drug? Also, why is a sustained release antidiabetic drug more beneficial?

What is Diabetes?

Diabetes is a chronic metabolic disorder, in which blood glucose/sugar level raised.
In case of diabetes mellitus, the beta cells of the pancreas are no longer able to make insulin (a hormone that regulates the tissues uptake of glucose) or unable to utilize the insulin present in the body.
Diabetes mellitus is of two types,

  • Type1 DM (Insulin-dependent diabetes mellitus or juvenile diabetes) generally occur when the body is unable to produce insulin.
  • Type2 DM (Non-insulin-dependent diabetes or adult-onset diabetes) generally occur when the body produces less insulin or is unable to use insulin properly.

The management of diabetes mellitus can be done by both lifestyle modification and proper antidiabetic medication.

Glimepiride, metformin, and voglibose are the third line antidiabetic drug for the management of type 2 diabetes mellitus.

It is the most widely preferred drug when diet, exercise, single therapy, and combination therapy (second line drug) are unable to control the raised blood glucose level.
It is available in the form of sustained release formulation.

How glimepiride+metformin+voglibose work?

It is the combination therapy of glimepiride (sulfonylurea), metformin (biguanides) and voglibose (alpha-glucosidase inhibitor).

  • Glimepiride is an insulin secretagogue; it decreases blood glucose level by stimulating the release of insulin from pancreatic beta cells, mainly by blocking ATP-sensitive potassium channel.
  • Metformin is an insulin sensitizer, and it reduces the production of glucose in the liver mainly by inhibiting gluconeogenesis (a metabolic pathway for the generation of glucose from protein and lipid) and glycogenolysis ( the process of breaking down glycogen into glucose)
  • Voglibose is an alpha-glucosidase inhibitor, which prevents the breakdown of complex sugar (oligosaccharides and disaccharides) into simple sugar (glucose).

Side effects related to the glimepiride+metformin+voglibose combination

USFDA approved it as a safe and effective third line drug for the management of type2 DM.
Some common side effects are Nausea, flatulence, stomach pain, hypoglycemia (low blood sugar level), diarrhoea, headachesand skin rashes.

Why is sustained release antidiabetic drug more beneficial?

Diabetes mellitus is a chronic disease, and the duration of treatment therapy is for a lifetime. The benefits of sustained release formulation are:

  • Improve patient compliance by reducing the frequency of dosing
  • Reduction in the amount of dose.
  • Reduced gastrointestinal side effects (such as diarrhoea, abdominal discomfort and flatulence) related to the antidiabetic drug.
  • Improve patient adherence with a simple dosing regimen.

To Conclude

Sustained release formulation improves patient compliance by reducing the frequency of dosing, and providing an extended duration of action with minimum side effects.

Glimepiride+Metformin+Voglibose combination is a third line antidiabetic drug for the management of type2 DM.

Dr Best Pharmaceuticals facilitates premium quality health care products in different therapeutic segments like cardiovascular agents, antidiabetic drugs, gastrointestinal agents, OTC drugs, Antibiotics, lipid profile management, Analgesics and Vitamins.

The antidiabetic drug Glimepiride 2 mg, metformin 500 mg + voglibose 0.2 mg (Sustained release tablet) are readily available with their online pharmacy 24 with huge discounts up to 80%. They provide medicines at an affordable price.

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