DR RAB DSR
DR RAB DSR
Pack: Strip of 10 Capsules
Composition : Rabeprazole Sodium 20 MG and Domperidone 30 MG SR Capsules
COMPOSITION : Each Capsule contains
RABEPRAZOLE 20 mg
DOMPERIDONE 30 mg
M.O.A : Rabeprazole belongs to class of medications called proton pump inhibitors. It blocks the activity of the proton pumps in the stomach wall that produce acid, thereby reducing the amount of acid produced in the stomach.
Domperidone belongs to a class of medicines known as anti-emetics. Domperidone acts by helping food move faster through the food pipe, stomach and gut; thus normalising the digestion process.
Suppresses gastric acid secretion by blocking acid (proton) pump within gastric parietal cells.
T max is 2 to 5 h. Oral bioavailability is approximately 52%.
Protein binding is 96.3%.
Extensively metabolized in liver by CYP3A to sulphone metabolite and CYP2C19 to desmethyl rabeprazole. Thioether and sulphone metabolites are formed by reduction of rabeprazole. These metabolites do not have significant antisecretory activity. CYP2C19 exhibits genetic polymorphism caused by deficiency in some subpopulations (white patients, 3% to 5%; Asian patients, 17% to 20%).
Plasma half-life is 1 to 2 h. Eliminated in urine (90% as thioether carboxylic acid, glucuronide, and mercapturic acid); remainder recovered in feces. No unchanged drug recovered.
INDICATION : The management of dyspepsia, heartburn, epigastric pain, nausea, and vomiting.
DOSAGE: As directed by the physician.
SIDE EFFECTS: Irritability, Dry mouth, Headache, Loss of interest in sex, Breast pain or tenderness, Abnormal heart rhythm, Drowsiness, Abnormal milk discharge from breast, Diarrhoea.
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