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Dr-Rab-Dsr

Rabeprazole Sodium and Domperidone SR Capsules

DR RAB DSR

Price: ₹30.00
Pack: Strip of 10 tablets.

Category:

COMPOSITION :   Each Capsule  contains

RABEPRAZOLE                     20 mg

DOMPERIDONE                   30 mg

M.O.A : Rabeprazole belongs to class of medications called proton pump inhibitors. It blocks the activity of the proton pumps in the stomach wall that produce acid, thereby reducing the amount of acid produced in the stomach.

Domperidone belongs to a class of medicines known as anti-emetics. Domperidone acts by helping food move faster through the food pipe, stomach and gut; thus normalising the digestion process.

PHARMACOLOGY:

Suppresses gastric acid secretion by blocking acid (proton) pump within gastric parietal cells.

PHARMACOKINETICS

Absorption

max is 2 to 5 h. Oral bioavailability is approximately 52%.

Distribution

Protein binding is 96.3%.

Metabolism

Extensively metabolized in liver by CYP3A to sulphone metabolite and CYP2C19 to desmethyl rabeprazole. Thioether and sulphone metabolites are formed by reduction of rabeprazole. These metabolites do not have significant antisecretory activity. CYP2C19 exhibits genetic polymorphism caused by deficiency in some subpopulations (white patients, 3% to 5%; Asian patients, 17% to 20%).

Elimination

Plasma half-life is 1 to 2 h. Eliminated in urine (90% as thioether carboxylic acid, glucuronide, and mercapturic acid); remainder recovered in feces. No unchanged drug recovered.

INDICATION  : The  management of dyspepsia, heartburn, epigastric pain, nausea, and vomiting.

DOSAGE As directed by the physician.

SIDE EFFECTS:  Irritability, Dry mouth, Headache, Loss of interest in sex, Breast pain or tenderness, Abnormal heart rhythm, Drowsiness, Abnormal milk discharge from breast, Diarrhoea.

S. No. COMPETITIOR COMPANY MRP / Tab
1 Rabesec-DSR Cipla 122/10
2 Rablet-D Lupin 125/10
3 Cyra-D Systopic 40/10
4 Rabicip-D CIPLA 100.50/10
4 Happi-D zydus cadila 113/10

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