Diabetes is a chronic metabolic disorder, occurs when life goes on the way you don’t think for it too!
Diabetes is characterized by an increase in blood glucose level (blood sugar level) due to inadequate secretion of insulin, or the body is unable to utilize insulin.
Diabetes is the effect of multiple factors and caused due to obesity (an increase in weight), a hectic lifestyle full of stress, improper sleep and unmanaged intake of sugar and processed food.
Type 2 Diabetes Mellitus (T2DM) is a non-insulin dependent diabetes mellitus, most common form of diabetes. It generally happens when the body is unable to utilize insulin properly or produces less insulin.
Anti-diabetic drugs, along with lifestyle modification, are most widely preferred for the management of diabetes.
Glibenclamide is an oral hypoglycemic agent, a second-generation sulfonylurea widely used in combination with Metformin for the management of T2DM.
So, lets discuss in detail about Glibenclamide!
Sulfonylurea is a class of oral hypoglycemic agents (medicines that lower the blood glucose level). It is the widely preferred second-line anti-diabetic drug for the management of type 2 diabetes mellitus (DM). Sulfonylurea shows anti-diabetic property by stimulating the release of insulin from the beta cells of the pancreas.
Glibenclamide is the second-generation sulfonylurea.
Glibenclamide also called as glyburide, and it is a second-generation sulfonylurea oral hypoglycemic agent. Glibenclamide is used either as monotherapy or in combination with biguanides for the management of type 2 diabetes mellitus (T2DM).
USFDA has approved Glibenclamide for medical use in 1984, and now it is widely available as a generic medication.
Glibenclamide is most preferred sulfonylurea for the management of gestational diabetes (high blood sugar develop during pregnancy) where other anti-diabetic drugs (Metformin and Insulin are ineffective or not tolerated).
How does Glibenclamide work?
Glibenclamide is an oral hypoglycemic agent, decreases body blood glucose level by inhibiting the ATP-sensitive potassium channel (KATP), causes cell membrane depolarization resulting increased intracellular calcium in beta cells of the pancreas and thus stimulate the release of insulin from pancreatic beta cells.
Glibenclamide is recommended, along with diet and exercise.
Side effects related to Glibenclamide:
Along with therapeutic benefits, every drug has a specific drawback and cause some severe side effect.
USFDA approved Glibenclamide in combination with Metformin as a safe and effective drug for the management of gestational diabetes.
The side effects related to Glibenclamide are Nausea, vomiting, constipation, diarrhoea, weight gain, hypoglycemia (low blood sugar level) and allergic reaction (itching, hives, skin rashes or blister).
The combination therapy of Glibenclamide 5 mg + Metformin 500 mg (DRMET GB) reduces the risk of hypoglycemia.
The usual starting dose of Glibenclamide is 5 mg daily, unless as per the prescription of your doctor. The prescribed single dose of glibenclamide can be taken with or immediately after breakfast. In case, if you forget to take the dose on your usual time, then take it with or after your next meal.
If you do not remember until the whole day then skips the missed dose, do not take two doses on the same day as this cause severe hypoglycemia and increase the risk of a life-threatening problem.
- Glibenclamide is contraindicated during pregnancy and lactation (breastfeeding).
- Do not take glibenclamide without the prescription of your doctor.
- It is contraindicated in diabetic ketoacidosis and Type 1 diabetes.
- It increases the risk of cardiovascular complication (heart attack and strokes).
- Before taking glibenclamide tell your doctor if you had: thyroid disorder, kidney problem, liver problem and prior episodes of an allergic reaction
- Contraindicated in elderly patient >65 years of age.
- It is contraindicated in children <18 years of age.
- Glibenclamide makes the skin more sensitive to the sun, thus increases the risk of sunburn. So, use sunscreen having SPF more than 30 and wear sun-protective clothing when going outside.
- Avoid the use of alcohol during glibenclamide treatment as it worsens the risk of hypoglycemia (low blood glucose level)
Combination of Glibenclamide 5 mg + Metformin 500 mg:
The fixed-dose combination therapy of Glibenclamide 5 mg + Metformin 500 mg (DRMET GB) reduces the risk of hypoglycemia (low blood sugar) and weight gain as the major problem with glibenclamide when given alone.
Concluding, Glibenclamide is safe and effective oral hypoglycemic agents when given in combination with Metformin (DRMET GB) for the management of Type 2 diabetes mellitus (T2DM)
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