Clopidogrel and Aspirin: Combination Therapy Stroke and Various Ischemic Events

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Clopidogrel-and-Aspirin

Stroke is a leading cause of morbidity and premature death globally!

The majority of stroke survivors continue to live with disabilities, and the costs of long-term treatment provide too much burden on the patient and his family. Stroke is a disease that affects the arteries leading to the brain. It occurs when a blood vessel that carries oxygen as well as nutrients to the brain ruptures or is blocked by the clot. Due to this, the part of the brain cannot get the blood (oxygen and nutrients), so brain cells die.

Stroke is a medical condition that needs immediate medical attention. It needs to be diagnosed and treated quickly to minimize brain damage. The most effective mode to prevent stroke is by maintaining a healthy lifestyle and managing the risk factors.

After a recent ischemic stroke, Clopidogrel is widely used in patients. It is a potent oral anti-platelet agent that is used in the treatment of coronary artery disease, cerebrovascular disease and peripheral vascular disease.

Aspirin reduces the risk of recurrent stroke approximately by 20%. These are two different classes of drugs. Clopidogrel is an anticoagulant drug, while aspirin is a non-steroidal anti-inflammatory drug (NSAID). Aspirin is used to reduce the pain, fever and inflammation. It also prevents blood clotting and is used to prevent a heart attack as well as stroke.

Clopidogrel inhibits the aggregation of platelet synergistically with Aspirin. These are anti-platelet medicines. Platelets are small blood cells which stick together during the blood clotting. These medicines prevent clumping and reduce the chances of forming a blood clot (Thrombosis)

Clopidogrel and Aspirin: Combination therapy

Clopidogrel and Aspirin in a fixed dose combination are more effective as compared to Aspirin and Clopidogrel alone in reducing the risk of stroke and various ischemic events. Clopidogrel inhibits the aggregation of platelet synergistically with Aspirin.

In combination with Aspirin, Clopidogrel is used to treat severe chest pain, unstable angina, myocardial infarction and other severe cardiac complications.

More significant benefits may be achieved through the combination therapy in the treatment of stroke. Due to the combination, low doses of Clopidogrel and Aspirin are administered, which gives more benefits without increasing the risk of bleeding events.
The combination may be prescribed to reduce the risk of heart attack and stroke if you have suffered severe chest pain (unstable angina) or had a heart attack.

Clopidogrel:  How does it work?

Clopidogrel works by preventing the platelets from sticking together and hence preventing them from forming clots. It is an anti-platelet drug which helps keep blood flowing smoothly.

Clopidogrel is a drug whose metabolite inhibit platelet aggregation. It is metabolized by the enzyme CYP450 for the production of an active metabolite which inhibits aggregation of platelets. The active metabolite of Clopidogrel inhibits the binding of adenosine diphosphate (ADP) to its platelet P2Y12 receptor, thereby inhibiting platelet aggregation.

  • Aspirin is an inhibitor of cyclooxygenase and prevents the synthesis of thromboxane A2 (TXA2), which is a potent vasoconstrictor and platelet aggregator. Hence, by inhibiting TXA2, it prevents the platelet aggregation and reduces 13–19% of the consequences of cardiac vascular events.
  • Clopidogrel inhibits the aggregation of platelet synergistically with Aspirin.

Benefits of Clopidogrel + Aspirin

Clopidogrel + Aspirin is used to prevent strokes and heart attacks in persons with heart disease or peripheral vascular disease (blood circulation disease).

  • In combination with Aspirin, Clopidogrel is used to treat severe chest pain, unstable angina and cardiac arrest.
  • It helps to keep the blood vessels open and prevents the blood clot.
  • It prevents myocardial infarction with peripheral arterial disease.
  • These are used to prevent the blood clots, which form hardened blood vessels (atherothrombosis), which can lead to severe cardiac complications like stroke, heart attack and death.
  • The combination may be prescribed to reduce the risk of heart attack and stroke if you have suffered severe chest pain (unstable angina) or had a heart attack.

Dosage and administration

The combination of Clopidogrel and Aspirin is well tolerated with a convenient once-a-day dosing schedule. The combination product of Clopidegrel and Aspirin is available in the form of tablets.
The dose of the medication depends upon the different factors like age, the severity of the disease, patient’s health, personal risk factors, etc. The dose for Clopidogrel and Aspirin is 75 mg and 100 mg, respectively, in a fixed-dose combination product.

Side effects of Clopidogrel + Aspirin

Generally, this combination is safe and well tolerated with minor side effects, which include bleeding, fever, headache and itchy skin.
The serious side effects of this combination include bleeding, which lasts for a long time, joint pain, upper respiratory tract infections, intracranial haemorrhage, blood in vomiting, as well as urine.

Warnings and Precautions

  • This product must be used with caution in patients with the history of the peptic ulcer because, due to the gastric ulcer, it may cause gastric bleeding.
  • It must not be used during the first two trimesters of pregnancy unless the clinical condition of the patient necessitates treatment with clopidogrel/Aspirin.
  • There is a pharmacodynamic interaction between heparin and Clopidogrel/Aspirin, which can lead to the risk of bleeding. Therefore, it should be undertaken with caution.
  • Overdose can lead to prolonged bleeding time and bleeding complications. Appropriate therapy must be considered if the bleedings are observed.

Conclusion

Dr. Best Pharmaceuticals provides various antiplatelet drugs along with antihypertensive medicines, hypolipidemic drugs, anti-diabetics, gastrointestinal and cardiovascular medication, analgesics, antibiotics, and vitamins at 80% less price in comparison to other branded medicines.

They provide this combination product as XKLOT (Clopidogrel 75 mg + Aspirin 75 mg) with an 80% discount, and you can get this product from their online pharmacy 24 hours a day. They are consistently working to provide premium-quality medicines and healthcare products so that no patient can suffer from the high cost of treatment. They are offering these online medicines with maximum discount to increase patient convenience.

Go for online medicine with Dr Best Pharmacy and get 80% discount on your medical bills with their online offers.

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