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Amoxicillin-Clavulanate: An Innovative Antimicrobial Combination


Antibiotics, a boon for bacterial infection!
A wide range of antibiotics is used in the treatment of several infections. Antibiotic resistance is a serious threat to medical advancements. Drug resistance to bacterial infections causes patient mortality and morbidity.

Infections with Multi-drug resistance (when a single bacteria produces resistance to more than one antibiotic) are challenging to treat because there is few or even no treatment options are available. In such a case, more toxic antibiotics need to be used for the treatment of infection because there is no other option; then it is called multi-drug resistant.

The recent developments for the treatment of multi-drug resistance (MDR) through which resistance mechanism is targeted are antibiotic+antibiotic combination, antibiotic+non antibiotic and the adjuvants therapy.

Amoxycillin-Clavulanate is a broad-spectrum antibacterial which inhibits the beta-lactamase-producing pathogens (which produces resistance) and offers favourable Pharmacokinetics/Pharmacodynamic profile. It is widely preferred for the treatment of respiratory tract infections.

Why is Amoxicillin-Clavulanate innovative combination?

The increase in multi-drug resistance, particularly for gram-negative bacteria indicates that monotherapy is no longer competent to treat bacterial infections. Thus it becomes necessary to use the combination therapy.

The first approach to overcome multi-drug resistance is a combination of two or more antimicrobial drugs. But the possibility of drug-drug interactions must be considered during the drug development process, which is not found in the case of Amoxicillin-Clavulanate.
Due to the presence of Clavunalic acid, there is inhibition of beta-lactamase enzyme (responsible for the development of resistance). Hence, the effectiveness of amoxicillin is increased.

It offers favourable Pharmacokinetics/Pharmacodynamic profile.

Uses of Amoxicillin-Clavulanate

  • This combination is used to treat various infections caused by bacteria like pneumonia, sinusitis, bronchitis, ear infections, urinary tract infections and skin infections.
  • Bone and joint infections, particularly osteomyelitis.
  • Cystitis, pyelonephritis, skin and other soft tissue infections.

How does it work?
Amoxicillin and clavulanate potassium extended-release tablets is an antibacterial combination of oral use. It consists of semi-synthetic antibacterial amoxicillin and salt of clavulanic acid. Amoxicillin stops the multiplication of bacteria by inhibiting the cell wall synthesis of bacteria.

The bacterial cell wall is essential to protect the bacteria from the environment and keep the contents of the bacterial cell together. Clavulanic acid inactivates the beta-lactamase enzyme by blocking its active sites. Beta-lactamase enzyme is responsible for the development of drug resistance; thus, clavulanic acid enhances the effectiveness of amoxicillin.

Dose of Amoxicillin-Clavulanate
The dose of Amoxicillin-Clavulanate depends upon various factors like age, type and severity of the condition which is going to treat and other medical conditions. The liquid suspension, immediate-release and extended-release tablets are available in different strengths.

  • Immediate-release tablets (amoxicillin/clavulanic acid) – 250mg/125 mg, 500mg/125 mg and 875mg/125mg
  • Extended-release tablets (amoxicillin/clavulanic acid) – 1000mg/62.5mg
  • Liquid Suspension (amoxicillin/clavulanic acid) – 125mg/31.25 and 250mg/62.5 mg per 5mL

Important Information regarding Amoxicillin-Clavulanate


  • Don’t use this medicine if you are suffering from kidney disease.
  • Avoid this medicine if you are allergic to any penicillin or cephalosporin derivatives.
  • It makes birth control pills less effective.
  • Don’t use this medication if you are a feeding mother.

Side effects related to Amoxicillin-Clavulanate
Amoxicillin-Clavulanate is generally safe and well-tolerated.
Some common side effects associated with this combination are abdominal discomfort, headache, nausea, vomiting, heartburn and diarrhoea.

Some severe side effects are reversible hepatitis, prolonged diarrhoea, rashes and allergic reactions.

Availability of cost-effective Amoxicillin-Clavulanate (Combination product)
Dr Best Pharmaceuticals is providing generic Amoxicillin-Clavulanate and other combination products (Ofloxacin-Ornidazole) along with anti-diabetics, analgesics, anti-hypertensive, antibiotics, hypolipidemic drugs, cardiovascular medicines, vitamins and many more products at 80% lesser price as compared to the other branded products.
They provide DRKLAV 625 (Amoxicillin 500mg + Clavulanate 125 mg) with 80% discount, and you can easily order this from their online pharmacy 24 hrs. They are providing these online medicines with a maximum discount for the convenience of patients.
Go for online medicine with Dr Best Pharmaceuticals and save your money with their online offers.

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