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Pack: Strip of 10 tablets.

Composition: Amlodipine Besylate 5 mg


COMPOSITION: Each tablet contains:-

Amlodipine   5 mg

M.O.A. :

Amlodipine belongs to a class of drugs called calcium channel blocker. It reduces the amount of calcium that enters the smooth muscles of the blood vessels and heart. As muscle cells require calcium to contract, reducing the flow of calcium causes the muscle cells to relax and blood vessels to dilate, reducing blood pressure, force and rate of the heartbeat. It improves blood and oxygen supply to the heart muscles.


Absorption, distribution, plasma protein binding

After oral administration of therapeutic doses, amlodipine is well absorbed with peak blood levels between 6-12 hours post dose. Absolute bioavailability has been estimated to be between 64 and 80%. The volume of distribution is approximately 21 l/kg. In vitro studies have shown that approximately 97.5% of circulating amlodipine is bound to plasma proteins.

The bioavailability of amlodipine is not affected by food intake.


The terminal plasma elimination half-life is about 35-50 hours and is consistent with once daily dosing. Amlodipine is extensively metabolised by the liver to inactive metabolites with 10% of the parent compound and 60% of metabolites excreted in the urine.

INDICATION  :  Prinzmetal’s angina, stable angina, Hypertension.

DOSAGE:  As directed by the Physician.

SIDE EFFECTS : Facial flushing, Extreme tiredness, Abdominal or stomach pain, Drowsiness, Upset stomach, Swelling of hands and feet, Dizziness, Chest pain, Lightheadedness, Fainting, Pounding heartbeat and headache.

4AmtasIntas31.58/105StamloDr. Reddy ‘s31.80/10

1 Amlopres Cipla (SSD) 31.84/10
2 Amlong Micro Caryson 32.86/10
3 Amlip Cipla 32.78/10

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