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Aceclofenac & Paracetamol Tablets


Price: ₹20.00
Pack: Strip of 10 tablets.


COMPOSITION  :  Each  Tablet  contains :-

Aceclofenac  100 mg

Paracetamol  325 mg

Pharmacokinetics :

Aceclofenac is a phenylacetic acid derivative that inhibits synthesis of the inflammatory cytokines interleukin-1b and tumour necrosis factor, and inhibits prostaglandin E2 production. It increases glycosaminoglycans (GAG) synthesis, the principal macromolecule of the extracellular matrix, which aids in repair and regeneration of articular cartilage. Thus, aceclofenac has +ve effects on cartilage anabolism combined with modulating effect of matrix catabolism. Paracetamol has analgesic and antipyretic action with weak anti-inflammatory activity. It produces analgesia by increasing pain threshold and antipyresis by acting on the hypothalamic heat-regulating centre.

Aceclofenac: Rapidly absorbed; almost 100% bioavailability; peak plasma levels reached about 1.25-3 hours after oral admin                           .

Aceclofenac: >99.7% bound to plasma proteins; distributes into synovial fluid.

Paracetamol: Distributes throughout most fluids of the body                   .

Aceclofenac: Probably metabolised by CYP2C9; average plasma elimination half-life: 4-4.3 hours.

Paracetamol: Mainly metabolised hepatically; plasma elimination half-life: 1-4 hours.

Aceclofenac: About two-thirds of the administered dose is removed in the urine, mainly as conjugated hydroxymetabolites.

Paracetamol: Most metabolites are removed in the urine within 24 hours

INDICATION  : Anti inflammatory

DOSAGE:  As directed by the physician

SIDE EFFECTS : Paracetamol: Nausea, allergic reactions, skin rashes, acute renal tubular necrosis.

Aceclofenac:  Diarrhoea, headache, vertigo,  dizzies, nervousness, tinnitus, depression, drowsiness, insomnia; fever, angioedema, bronchospasm, rashes; blooddyscrasias                                       .

Potentially Fatal: Paracetamol: Very rare, blood dyscrasias (eg, thrombocytopaenia, leucopaenia, neutropaenia, agranulocytosis); liver damage.

Aceclofenac: Severe GI bleeding; nephrotoxicity.

1 Acenac- P Medley 39/10
2 Dolokind Plus Mankind 25.80/10
3 Ibugesic -AP Cipla 47/10

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